Omega Therapeutics to Unveil Preclinical Data on Epigenomic Programming of MYC with Epigenomic Controllers as a Promising Therapeutic Approach in Non-Small Cell Lung Cancer at the 25th Annual ASGCT Meeting
- Regulation of MYC gene expression via epigenomic programming results in decreased viability of cancer cells in vitro and reduced tumor burden in in vivo xenograft models
- Data demonstrate potential of Omega Epigenomic Controllers (OEC) to be developed as standalone therapy or in combination with standard of care therapies in non-small cell lung cancer (NSCLC)
- Data showcase capabilities of the OMEGA platform to identify key epigenomic intervention points and engineer programmable epigenetic mRNA medicines, epigenomic controllers, that precisely and durably regulate gene expression
"These preclinical data establish epigenomic programming as a differentiated approach to correct aberrant MYC expression by control of its insulated genomic domain (IGD) in NSCLC, which accounts for almost 25% of cancer deaths worldwide," said
Details for the poster presentation:
Title: Novel Epigenetic Targeting of the MYC Oncogene for the Treatment of NSCLC using programmable mRNA therapeutics
Abstract #: 1114
Date and Time: Wednesday, May 18, 2022, from
Key findings:
- OEC treatment yields precise, targeted changes in the epigenetic landscape of the MYC IGD in NSCLC cell lines
- Epigenetic changes drive robust downregulation of both MYC mRNA and protein in multiple NSCLC cell lines, leading to associated changes in MYC-driven genes and an increase in cell death via apoptosis
- Treatment with the OEC did not strongly impact the viability of healthy primary lung epithelial and endothelial cells
- Combining OEC treatment with either a MEK or EGFR inhibitor in NSCLC cells yielded greater reductions in MYC protein and cell viability, suggesting the potential for additive or synergistic effects of the OEC with standard of care therapies in patients
- OEC treatment effectively reduced tumor growth in vivo and was well tolerated in murine xenograft models, further supporting the therapeutic potential of this asset
The poster will be made available on the Omega website following the presentation at https://omegatherapeutics.com/our-science/#publications-research
About
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Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including without limitation statements regarding details of the presentation; potential of OEC to be developed as standalone therapy or in combination with standard of care therapies in NSCLC; the capabilities of our OMEGA Epigenomic Programming™ platform; the therapeutic potential of OEC treatment; and our product pipeline. These statements are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements, including, but not limited to, the following: the novel technology on which our product candidates are based makes it difficult to predict the time and cost of preclinical and clinical development and subsequently obtaining regulatory approval, if at all; the substantial development and regulatory risks associated with epigenomic controller machines due to the novel and unprecedented nature of this new category of medicines; our limited operating history; the incurrence of significant losses and the fact that we expect to continue to incur significant additional losses for the foreseeable future; our need for substantial additional financing; our investments in research and development efforts that further enhance the OMEGA platform, and their impact on our results; uncertainty regarding preclinical development, especially for a new class of medicines such as epigenomic controllers; the fact that our product candidates may be associated with serious adverse events, undesirable side effects or have other properties that could halt their regulatory development, prevent their regulatory approval, limit their commercial potential, or result in significant negative consequences; the impact of increased demand for the manufacture of mRNA and LNP based vaccines to treat COVID-19 on our development plans; difficulties manufacturing the novel technology on which our OEC candidates are based; our ability to adapt to rapid and significant technological change; our reliance on third parties for the manufacture of materials; our ability to successfully acquire and establish our own manufacturing facilities and infrastructure; our reliance on a limited number of suppliers for lipid excipients used in our product candidates; our ability to advance our product candidates to clinical development; and our ability to obtain, maintain, enforce and adequately protect our intellectual property rights. These and other important factors discussed under the caption "Risk Factors" in our Annual Report on Form 10-K for the period ended
Contacts
Media contact:
Jason Braco
646.751.4361
jbraco@lifescicomms.com
Investor contact:
212.600.1902
ArgotOmega@argotpartners.com
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